Biomarker Alzheimer’s disease: Alternatively consider multiple, neurodegenerative diseases• Name of biomarker: Brain volume /ml• Disease: Alzheimer’s disease: alternatively consider multiple, neurodegenerative diseases.• Modality: In MRI• Comment: could consider brain Subregions e.g. hippocampusReport (including tables but excluding references and figures; figures to occupy no more than one page)• What does the selected imaging biomarker purport to measure? (accurate reporting)• How is it measured? (accurate reporting)• How is it best classified? (accurate reporting)• What are the key publications (reviews, meta- analyses, consensus guidelines etc) that describe the measurement and interpretation of this biomarker…• …and what do they conclude? (accurate reporting)• Clarity of writing and organization of material• Professional standard of layout, formatting and citation